@article{fdi:010040943,
  title = {{A}ntiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-{N}-oxide derivatives},
  author = {{M}arin, {A}. and {L}ima, {L}. {M}. and {S}olano, {B}. and {V}icente, {E}. and {S}ilanes, {S}. {P}. and {M}aurel, {S}{\'e}verine and {S}auvain, {M}ichel and {A}ldana, {I}. and {M}onge, {A}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{D}erivatives of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-{N}-oxide (4b-g, 5b-g, 6a-g) were synthesized and evaluated for their capacity to inhibit the growth of chloroquine-resistant {P}lasmodium falciparum {FCB}1 strain in culture. {C}ompound 7-chloro-2-(2-furylcarbonyl)-3-trifluoromethyl-1,4-quinoxaline di-{N}-oxide (5g) was the most active being almost 5 times more active than chloroquine. {I}t was also 50 times more active against {P}. falciparum than toxic toward {MCF}7 cells. {S}tructural characteristics for a quinoxaline to be active were defined: bioisosteric modification of phenyl group by 2-thienyl or 2-furyl subunits, {R}2 position must be free or occupied by a methyl group and {R}1 position must be free or occupied by {C}l, {CH}3, {OCH}3 or {CF}3.},
  keywords = {},
  booktitle = {},
  journal = {{E}xperimental {P}arasitology},
  volume = {118},
  numero = {1},
  pages = {25--31},
  ISSN = {0014-4894},
  year = {2008},
  DOI = {10.1016/j.exppara.2007.05.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040943},
}