Orlandi Pradines E. auteur aut IRD Almeras L. auteur aut IRD Senneville L.D. de auteur aut IRD Barbe S. auteur aut IRD Remoué Franck auteur aut IRD Villard C. auteur aut IRD Cornélie Sylvie auteur aut IRD Penhoat K. auteur aut IRD Pascual A. auteur aut IRD Bourgouin C. auteur aut IRD Fontenille Didier auteur aut IRD Bonnet Julien auteur aut IRD Corre Catelin N. auteur aut IRD Reiter P. auteur aut IRD Pages F. auteur aut IRD Laffite D. auteur aut IRD Boulanger Denis auteur aut IRD Simondon François auteur aut IRD Pradines B. auteur aut IRD Fusai T. auteur aut IRD Rogier C. auteur aut IRD text journalArticle eng text/pdf born digital access Exposure to vectors of infectious diseases has been associated with antibody responses against salivary antigens of arthropods among people living in endemic areas. This immune response has been proposed as a surrogate marker of exposure to vectors appropriate for evaluating the protective efficacy of antivectorial devices. The existence and potential use of such antibody responses in travellers transiently exposed to Plasmodium or arbovirus vectors in tropical areas has never been investigated. The IgM and IgG antibody responses of 88 French soldiers against the saliva of Anopheles gambiae and Aedes aegypti were evaluated before and after a 5-month journey in tropical Africa. Antibody responses against Anopheles and Aedes saliva increased significantly in 41% and 15% of the individuals, respectively, and appeared to be specific to the mosquito genus. A proteomic and immunoproteomic analysis of anopheles and Aedes saliva allowed for the identification of some antigens that were recognized by most of the exposed individuals. These results suggest that antibody responses to the saliva of mosquitoes could be considered as specific surrogate markers of exposure of travellers to mosquito vectors that transmit arthropod borne infections. specialized malaria arbovirus vectors saliva antibody response proteomic travellers Anopheles gambiae Aedes aegypti 052 9 12-13 1454-1462 2007 1286-4579 https://www.documentation.ird.fr/hor/fdi:010040912 10.1016/j.micinf.2007.07.012 1286-4579 [F B010040912] https://www.documentation.ird.fr/hor/fdi:010040912 https://www.documentation.ird.fr/intranet/publi/2008/01/010040912.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-02-22 2017-08-23 fdi:010040912 fre