@article{fdi:010040849,
  title = {{E}valuation of antibody response to {P}lasmodium falciparum in children according to exposure of {A}nopheles gambiae s.l or {A}nopheles funestus vectors - art. no. 117},
  author = {{S}arr, {J}ean {B}iram and {R}emoue, {F}ranck and {S}amb, {B}. and {D}ia, {I}. and {G}uindo, {S}. and {S}ow, {C}heikh and {M}aiga, {S}. and {T}ine, {S}. and {T}hiam, {C}. and {S}chacht, {A}. {M}. and {S}imondon, {F}ran{\c{c}}ois and {K}onate, {L}. and {R}iveau, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n sub-{S}aharan areas, malaria transmission was mainly ensured by {A}nopheles. gambiae s. l. and {A}nopheles. funestus vectors. {T}he immune response status to {P}lasmodium falciparum was evaluated in children living in two villages where malaria transmission was ensured by dissimilar species of {A}nopheles vectors ( {A}n. funestus vs {A}n. gambiae s. l.). {M}ethods: {A} multi-disciplinary study was performed in villages located in {N}orthern {S}enegal. {T}wo villages were selected: {M}boula village where transmission is strictly ensured by {A}n. gambiae s. l. and {G}ankette {B}alla village which is exposed to several {A}nopheles species but where {A}n. funestus is the only infected vector found. {I}n each village, a cohort of 150 children aged from one to nine years was followed during one year and {I}g{G} response directed to schizont extract was determined by {ELISA}. {R}esults: {S}imilar results of specific {I}g{G} responses according to age and {P}. falciparum infection were observed in both villages. {S}pecific {I}g{G} response increased progressively from one-year to 5-year old children and then stayed high in children from five to nine years old. {T}he children with {P}. falciparum infection had higher specific antibody responses compared to negative infection children, suggesting a strong relationship between production of specific antibodies and malaria transmission, rather than protective immunity. {I}n contrast, higher variation of antibody levels according to malaria transmission periods were found in {M}boula compared to {G}ankette {B}alla. {I}n {M}boula, the peak of malaria transmission was followed by a considerable increase in antibody levels, whereas low and constant anti-malaria {I}g{G} response was observed throughout the year in {G}ankette {B}alla. {C}onclusion: {T}his study shows that the development of anti-malaria antibody response was profoundly different according to areas where malaria exposure is dependent with different {A}nopheles species. {T}hese results are discussed according to i) the use of immunological tool for the evaluation of malaria transmission and ii) the influence of {A}nopheles vectors species on the regulation of antibody responses to {P}. falciparum.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  numero = {},
  pages = {{NIL}_1--{NIL}_9},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-117},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040849},
}