Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES American Journal of Tropical Medicine and Hygiene 411-417 2007 fdi:010040787 ENG American Journal of Tropical Medicine and Hygiene 0002-9637 CC:0002493122-0002 3 https://www.documentation.ird.fr/hor/fdi:010040787 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010040787.pdf 77 Horizon (IRD) Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-con trolled trial of seasonal intermittent preventive anti-malarial treatment on growth and nutritional status in 1,063 Senegalese preschool children. A combination of artesunate and sulfadoxine-pyrimethamine was given monthly from September to November. In the intervention arm, mean weight gain was significantly greater (122.9 +/- 340 versus 42.9 +/- 344 [SD] g/mo, P < 0.0001) and losses in triceps and subscapular skinfold measurements were less (-0.39 +/- 1.01 versus -0.66 +/- 1.01 mm/mo, and -0.15 +/- 0.64 versus -0.36 +/- 0.62 mm/mo, respectively, P < 0.0001 for both). There was no difference in height increments. The prevalence of wasting increased significantly in the control arm (4.6% before versus 9.5% after, P < 0.0001), but remained constant in intervention children: 5.6% versus 7.0% (P = 0.62). The prevention of malaria would improve child nutritional status in areas with seasonal transmission. 052 ; 054