%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ntab, Balthazar
%A Cissé, Badara
%A Boulanger, Denis
%A Sokhna, Cheikh
%A Targett, G.
%A Lines, J.
%A Alexander, N.
%A Trape, Jean-François
%A Simondon, François
%A Greenwood, B. M.
%A Simondon, Kirsten
%T Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (West africa)
%D 2007
%L fdi:010040787
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%M CC:0002493122-0002
%N 3
%P 411-417
%U https://www.documentation.ird.fr/hor/fdi:010040787
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010040787.pdf
%V 77
%W Horizon (IRD)
%X Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-con trolled trial of seasonal intermittent preventive anti-malarial treatment on growth and nutritional status in 1,063 Senegalese preschool children. A combination of artesunate and sulfadoxine-pyrimethamine was given monthly from September to November. In the intervention arm, mean weight gain was significantly greater (122.9 +/- 340 versus 42.9 +/- 344 [SD] g/mo, P < 0.0001) and losses in triceps and subscapular skinfold measurements were less (-0.39 +/- 1.01 versus -0.66 +/- 1.01 mm/mo, and -0.15 +/- 0.64 versus -0.36 +/- 0.62 mm/mo, respectively, P < 0.0001 for both). There was no difference in height increments. The prevalence of wasting increased significantly in the control arm (4.6% before versus 9.5% after, P < 0.0001), but remained constant in intervention children: 5.6% versus 7.0% (P = 0.62). The prevention of malaria would improve child nutritional status in areas with seasonal transmission.
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