@article{fdi:010040785,
  title = {{M}olecular epidemiology of malaria in {C}ameroon. {XXV}. {I}n vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of {P}lasmodium falciparum and sequence analysis of 1-{D}eoxy-{D}-{X}ylulose 5-phosphate reductoisomerase},
  author = {{T}ahar, {R}achida and {B}asco, {L}eonardo},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he in vitro activities of fosmidomycin derivatives, chloroquine, and pyrimethamine were assessed by the radioisotopic assay in clinical isolates of {P}lasmodium falciparum. {I}n a series of experiments with {RPMI} 1640 medium-10% fetal bovine serum, the geometric mean 50% inhibitory concentrations ({IC}(50)s) (n = 34) for fosmidomycin and {FR}900098 were 301. n{M} and 118 n{M}, respectively. {I}n another series of experiments, the geometric mean {IC}(50)s (n = 33) for fosmidomycin and {TH} {I}146 were 413 n{M} and 249 n{M}, respectively. {T}he {IC}(50)s were 2-3 times lower with {RPMI}-10% fetal bovine serum than the {IC}(50)s obtained with {RPMI}-10% human serum. {FR}900098 and {TH} {II}46 were 2.6 and 1.7 times more potent, respectively, than fosmidomycin. {T}here was no correlation between chloroquine or pyrimethamine and fosmidomycin, which suggested the absence of in vitro cross-resistance. {S}equence analysis showed five amino acid substitutions, but their possible relationship with the response to fosmidomycin is not clear. {F}osmidomycin derivatives are promising candidates for further development.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {77},
  numero = {2},
  pages = {214--220},
  ISSN = {0002-9637},
  year = {2007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040785},
}