Roumy V. auteur aut IRD Garcia Pizango G. auteur aut IRD Gutierrez Choquevilca A. L. auteur aut IRD Ruiz L. auteur aut IRD Jullian Valérie auteur aut IRD Winterton P. auteur aut IRD Fabre N. auteur aut IRD Moulis C. auteur aut IRD Valentin A. auteur aut IRD text journalArticle eng text/pdf born digital access Indigenous Quechua and Mestizo populations from distinct areas in Loreto, Peru, were interviewed about traditional medication for the treatment of malaria. An ethnographic survey concerning the native theory of illness aetiology in the specific case of malaria permitted the elaboration of an efficient ethnopharmacological enquiry. The survey took place on three main zones corresponding to villages on the Napo and the Pastaza rivers (for the Quechua), and in the surroundings of Iquitos (for the Mestizos) and led to the collection of 14 plants. Serial extractions in hexane, dichloromethane, and methanol were performed on the different parts of the plants collected. The extracts were then tested for antiplasmodial activity in vitro. Seven plants displayed antiplasmodial activity (IC50 from 2 to 25 mu g/mL) and usually low cytotoxicity, indicating their antiplasmodial specificity. The results give scientific validation to the traditional medical knowledge of Quechua and Mestizo populations from Loreto and confirm a source of potentially active plants. specialized malaria Loreto in vitro screening Quechua ethnomedicine Peru 076 052 112 3 482-489 2007 0378-8741 https://www.documentation.ird.fr/hor/fdi:010040781 10.1016/j.jep.2007.04.009 0378-8741 [F B010040781] https://www.documentation.ird.fr/hor/fdi:010040781 https://www.documentation.ird.fr/intranet/publi/2007/10/010040781.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2007-11-06 2017-08-23 fdi:010040781 fre