Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Journal of Ethnopharmacology 482-489 malaria Loreto in vitro screening Quechua ethnomedicine Peru 2007 fdi:010040781 ENG Journal of Ethnopharmacology 0378-8741 CC:0002484672-0010 3 10.1016/j.jep.2007.04.009 https://www.documentation.ird.fr/hor/fdi:010040781 https://www.documentation.ird.fr/intranet/publi/2007/10/010040781.pdf 112 Horizon (IRD) Indigenous Quechua and Mestizo populations from distinct areas in Loreto, Peru, were interviewed about traditional medication for the treatment of malaria. An ethnographic survey concerning the native theory of illness aetiology in the specific case of malaria permitted the elaboration of an efficient ethnopharmacological enquiry. The survey took place on three main zones corresponding to villages on the Napo and the Pastaza rivers (for the Quechua), and in the surroundings of Iquitos (for the Mestizos) and led to the collection of 14 plants. Serial extractions in hexane, dichloromethane, and methanol were performed on the different parts of the plants collected. The extracts were then tested for antiplasmodial activity in vitro. Seven plants displayed antiplasmodial activity (IC50 from 2 to 25 mu g/mL) and usually low cytotoxicity, indicating their antiplasmodial specificity. The results give scientific validation to the traditional medical knowledge of Quechua and Mestizo populations from Loreto and confirm a source of potentially active plants. 076 ; 052