@article{fdi:010040757,
  title = {{S}equence diversity and differential expression of {T}c52 immuno-regulatory protein in {T}rypanosoma cruzi : potential implications in the biological variability of strains},
  author = {{M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise and {B}osseno, {M}arie-{F}rance and {G}arzon, {E}dwin and {L}eli{\`e}vre, {J}. and {S}ereno, {D}enis and {O}uaissi, {A}li and {B}reni{\`e}re, {S}imone {F}r{\'e}d{\'e}rique},
  editor = {},
  language = {{ENG}},
  abstract = {{T}rypanosoma cruzi is highly heterogeneous in terms of genetics and biological properties. {T}o explore the diversity of {T}. cruzi, we focused our study on the {T}. cruzi {T}c52 protein playing a critical immunosuppressive role during infection. {S}equence variability and expression levels of this virulence factor were analysed in various strains. {A}mong the 40 amino acid substitutions detected in the {T}c52 coding sequences, three substitutions may have an impact on protein activity or function, as two are localized in sites involved in the glutathione binding and the third is present in the region bearing immunomodulatory function. {T}his sequence variability was consistent with the genetic subdivisions of {T}. cruzi. {M}oreover, we observed that the level of {T}c52 transcripts and proteins varied between the different strains, but we did not find a significant correlation between {T}c52 expression and the phylogeny of the parasite. {T}hus, both diversity in the sequences and differences in the expression levels of {T}c52 protein may be involved in the biological variability of {T}. cruzi, especially in virulence and immunosuppression properties of {T}. cruzi strains.},
  keywords = {},
  booktitle = {},
  journal = {{P}arasitology {R}esearch},
  volume = {101},
  numero = {5},
  pages = {1355--1363},
  ISSN = {0932-0113},
  year = {2007},
  DOI = {10.1007/s00436-007-0651-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040757},
}