%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Aubouy, Agnès
%A Fievet, Nadine
%A Bertin, Gwladys
%A Sagbo, Jean C.
%A Kossou, H.
%A Kinde Gazard, D.
%A Kiniffo, R.
%A Massougbodji, A.
%A Deloron, Philippe
%T Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin
%D 2007
%L fdi:010040704
%G ENG
%J Tropical Medicine and International Health
%@ 1360-2276
%K falciparum malaria ; chloroquine ; sulfadoxine pyrimethamine ; mefloquine ; drug efficacy ; benin
%M CC:0002475620-0012
%N 7
%P 886-894
%R 10.1111/j.1365-3156.2007.01859.x
%U https://www.documentation.ird.fr/hor/fdi:010040704
%> https://www.documentation.ird.fr/intranet/publi/2007/09/010040704.pdf
%V 12
%W Horizon (IRD)
%X Objective To evaluate the in vivo therapeutic efficacy of chloroquine (CQ), sulfadoxine-pyrimethamine (SP) and mefloquine (MQ) in children presenting with uncomplicated malaria in Benin. Methods Drug efficacy was tested according to the WHO in vivo 28-day protocol. For failures that occurred after 7 days of follow-up, paired pre- and post-treatment blood samples were genotyped at msp1 and msp2 loci to distinguish new infections and recrudescent strains. Children enrolled were randomly assigned to a therapeutic group (CQ, n = 14; SP, n = 42; MQ, n = 44). The number of CQ treatment was intentionally restricted after 1 month, as its use was considered to constitute a danger for children. Results Chloroquine and SP showed very high failure rates (85.7% and 50%, respectively), whereas MQ treatment was successful in 97.5%. The molecular tool allowed to re-evaluate two new infections previously considered as failures. Conclusions Chloroquine should no longer be used to treat children presenting with Plasmodium falciparum malaria in Benin.
%$ 052