@article{fdi:010040602,
  title = {{S}creening for tuberculosis among 2381 household contacts of sputum-smear-positive cases in {T}he {G}ambia},
  author = {{J}ackson {S}illah, {D}. and {H}ill, {P}. {C}. and {F}ox, {A}. and {B}rookes, {R}. {H}. and {D}onkor, {S}. {A}. and {L}ugos, {M}. {D}. and {H}owie, {S}. {R}. {C}. and {F}ielding, {K}. {R}. and {J}allow, {A}. and {L}ienhardt, {C}hristian and {C}orrah, {T}. and {A}degbola, {R}. {A}. and {M}c{A}dam, {K}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontact investigation is a key component of tuberculosis ({TB}) control in developed, but not developing, countries. {W}e aimed to measure the prevalence of {TB} among household contacts of sputum-smear-positive {TB} cases in {T}he {G}ambia and to assess the sensitivity of an enzyme-linked immunospot ({ELISPOT}) assay in this regard. {H}ousehold contacts of adult smear-positive {TB} patients were assessed by questionnaire, purified protein derivative ({PPD}) skin test, {ELISPOT} assay, physical examination, chest {X}-ray and sputum/gastric aspirate. {T}hirty-three {TB} cases were identified from 2174 of 2381 contacts of 317 adult smear-positive pulmonary {TB} patients, giving a prevalence of 1518/100000. {T}he cases identified tended to have milder disease than those passively detected. {T}he sensitivity of {ESAT}-6/{CFP}-10 {ELISPOT} test as a screening test for {TB} disease was estimated as 71%. {F}ifty-six per cent of contacts with a {PPD} skin test result >= 10 mm induration had detectable responses to {ESAT}-6/{CFP}-10 by {ELISPOT}, 11% with a negative {PPD} skin test (<10 mm) had a positive {ESAT}-6/{CFP}-10 response. {A}ctive screening for {TB} among contacts of {TB} patients may have a role in {TB} control in {T}he {G}ambia. {T}hese individuals are a high-risk group, and the disease identified is less advanced than that found through passive case detection. {A}n {ELISPOT} assay was relatively insensitive as a screening test for {TB}.},
  keywords = {tuberculosis ; {M}ycobacterium tuberculosis ; screening ; tuberculin skin test ; {ELISPOT} ; {T}he {G}ambia},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {101},
  numero = {6},
  pages = {594--601},
  ISSN = {0035-9203},
  year = {2007},
  DOI = {10.1016/j.trstmh.2007.02.001},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040602},
}