Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Phytochemistry 1312-1320 Piper hostmanniantun var. berbicense Piperaceae dihydrochalcones flavanones antiplasmodial activity Plasimodium falciparum 2007 fdi:010040596 ENG Phytochemistry 0031-9422 CC:0002466355-0012 9 10.1016/j.phytochem.2007.02.006 https://www.documentation.ird.fr/hor/fdi:010040596 https://www.documentation.ird.fr/intranet/publi/2007/07/010040596.pdf 68 Horizon (IRD) The bioassay-guided purification of an n-hexane extract from the leaves of Piper hostmannianum var. berbicense led to the isolation of four monoterpene or prenyl-substituted dihydrochalcones (1a, 1b, 2, 3) as well as the known compounds 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone (4), linderatone (5), strobopinin (6), adunctin E (7) and (-)-methyllinderatin (8). Their structures were established on the basis of NMR and X-ray analysis. (-)-Methyllinderatin, linderatone and 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone exhibited the most potent antiplasmodial activity with IC50 values of 5.64, 10.33 and 12.69 mu M, respectively against both chloroquine-sensitive and resistant strains of Plasmodium falciparum (F32, FcBl). The activity of (-)-methyllinderatin was confirmed in vivo against Plasmodium vinckei petteri in mice (80% of reduction of parasitemia) at a dose of 20 mg/kg/day. 076 ; 020