%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Portet, B.
%A Fabre, N.
%A Roumy, V.
%A Gornitzka, H.
%A Bourdy, Geneviève
%A Chevalley, Séverine
%A Sauvain, Michel
%A Valentin, A.
%A Moulis, C.
%T Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense
%D 2007
%L fdi:010040596
%G ENG
%J Phytochemistry
%@ 0031-9422
%K Piper hostmanniantun var. berbicense ; Piperaceae ; dihydrochalcones ; flavanones ; antiplasmodial activity ; Plasimodium falciparum
%M CC:0002466355-0012
%N 9
%P 1312-1320
%R 10.1016/j.phytochem.2007.02.006
%U https://www.documentation.ird.fr/hor/fdi:010040596
%> https://www.documentation.ird.fr/intranet/publi/2007/07/010040596.pdf
%V 68
%W Horizon (IRD)
%X The bioassay-guided purification of an n-hexane extract from the leaves of Piper hostmannianum var. berbicense led to the isolation of four monoterpene or prenyl-substituted dihydrochalcones (1a, 1b, 2, 3) as well as the known compounds 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone (4), linderatone (5), strobopinin (6), adunctin E (7) and (-)-methyllinderatin (8). Their structures were established on the basis of NMR and X-ray analysis. (-)-Methyllinderatin, linderatone and 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone exhibited the most potent antiplasmodial activity with IC50 values of 5.64, 10.33 and 12.69 mu M, respectively against both chloroquine-sensitive and resistant strains of Plasmodium falciparum (F32, FcBl). The activity of (-)-methyllinderatin was confirmed in vivo against Plasmodium vinckei petteri in mice (80% of reduction of parasitemia) at a dose of 20 mg/kg/day.
%$ 076 ; 020