@article{fdi:010040596,
  title = {{A}ctivity-guided isolation of antiplasmodial dihydrochalcones and flavanones from {P}iper hostmannianum var. berbicense},
  author = {{P}ortet, {B}. and {F}abre, {N}. and {R}oumy, {V}. and {G}ornitzka, {H}. and {B}ourdy, {G}enevi{\`e}ve and {C}hevalley, {S}{\'e}verine and {S}auvain, {M}ichel and {V}alentin, {A}. and {M}oulis, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he bioassay-guided purification of an n-hexane extract from the leaves of {P}iper hostmannianum var. berbicense led to the isolation of four monoterpene or prenyl-substituted dihydrochalcones (1a, 1b, 2, 3) as well as the known compounds 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone (4), linderatone (5), strobopinin (6), adunctin {E} (7) and (-)-methyllinderatin (8). {T}heir structures were established on the basis of {NMR} and {X}-ray analysis. (-)-{M}ethyllinderatin, linderatone and 2 ',6 '-dihydroxy-4 '-methoxydihydrochalcone exhibited the most potent antiplasmodial activity with {IC}50 values of 5.64, 10.33 and 12.69 mu {M}, respectively against both chloroquine-sensitive and resistant strains of {P}lasmodium falciparum ({F}32, {F}c{B}l). {T}he activity of (-)-methyllinderatin was confirmed in vivo against {P}lasmodium vinckei petteri in mice (80% of reduction of parasitemia) at a dose of 20 mg/kg/day.},
  keywords = {{P}iper hostmanniantun var. berbicense ; {P}iperaceae ; dihydrochalcones ; flavanones ; antiplasmodial activity ; {P}lasimodium falciparum},
  booktitle = {},
  journal = {{P}hytochemistry},
  volume = {68},
  numero = {9},
  pages = {1312--1320},
  ISSN = {0031-9422},
  year = {2007},
  DOI = {10.1016/j.phytochem.2007.02.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040596},
}