@article{fdi:010037957,
  title = {{Q}uassia amara {L}. ({S}imaroubaceae) leaf tea : {E}ffect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation},
  author = {{B}ertani, {S}. and {H}ouel, {E}. and {B}ourdy, {G}enevi{\`e}ve and {S}tien, {D}. and {J}ullian, {V}al{\'e}rie and {L}andau, {I}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n {F}rench {G}uiana, {Q}uassia amara {L}. ({S}imaroubaceae) leaf tea is a well-known widely used traditional antimalarial remedy. {I}mpact of the vegetal sampling condition on in vivo and in vitro antimalarial activity was assessed. {T}raditional infusions were prepared with juvenile or mature leaves, both either fresh or dried. {R}esults showed that growing stage and freshness of vegetal material exert a striking effect on antimalarial activity, both in vitro and in vivo. {B}y far, leaf tea made from fresh juvenile ({FJ}) {Q}uassia amara leaves was the most active. {I}n vitro, active component (simalikalactone {D}) concentration correlates biological activities, although unexplained subtle variations were observed. {I}n vivo, tea made with dried juvenile ({DJ}) leaves displays a peculiar behavior, meaning that some components may help simalikalactone {D} delivery or may be active in vivo only, therefore enhancing the expected curative effect of the traditional preparation.},
  keywords = {antimalarial ; {Q}uassia amara ; quassinoids ; simalikalactone {D} ; traditional medicine},
  booktitle = {},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {111},
  numero = {1},
  pages = {40--42},
  ISSN = {0378-8741},
  year = {2007},
  DOI = {10.1016/j.jep.2006.10.028},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037957},
}