@article{fdi:010037931,
  title = {{S}ynergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against {A}nopheles gambiae - art. no. 38},
  author = {{P}ennetier, {C}{\'e}dric and {C}orbel, {V}incent and {B}oko, {P}. and {O}djo, {A}. and {N}' {G}uessan, {R}. and {L}apied, {B}. and {H}ougard, {J}ean-{M}arc},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}o manage the kdr pyrethroid-resistance in {A}nopheline malaria vectors, new compounds or new strategies are urgently needed. {R}ecently, mixing repellents ({DEET}) and a non-pyrethroid insecticide (propoxur) was shown to be as effective as deltamethrin, a standard pyrethroid, under laboratory conditions, because of a strong synergy between the two compounds. {I}n the present study, the interactions between two repellents ({DEET} and {KBR} 3023) and a non-pyrethroid insecticide (pyrimiphos methyl or {PM}) on netting were investigated. {T}he residual efficacy and the inhibition of blood feeding conferred by these mixtures were assessed against {A}nopheles gambiae mosquitoes. {M}ethods: {DEET} and {KBR} 3023 were mixed with pyrimiphos methyl ({PM}), a organophosphate ({OP}) insecticide. {T}he performance of mono- and bi-impregnated nets against adult mosquitoes was assessed using a miniaturized, experimental hut system (laboratory tunnel tests) that allows expression of behavioural responses to insecticide, particularly the mortality and blood feeding effects. {R}esults: {B}oth mixtures ({PM}+{DEET} and {PM}+{KBR}3023) induced 95% mortality for more than two months compared with less than one week for each compound used alone, then reflecting a strong synergy between the repellents and {PM}. {A} similar trend was observed with the blood feeding rates, which were significantly lower for the mixtures than for each component alone. {C}onclusion: {S}ynergistic interactions between organophosphates and repellents may be of great interest for vector control as they may contribute to increase the residual life of impregnated materials and improve the control of pyrethroid-resistance mosquitoes. {T}hese results prompt the need to evaluate the efficacy of repellent/non-pyrethroid insecticide mixtures against field populations of {A}n. gambiae showing high level of resistance to {O}ps and pyrethroids.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  numero = {},
  pages = {{NIL}_1--{NIL}_7},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-38},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037931},
}