@article{fdi:010037901,
  title = {{I}s chloroquine chemoprophylaxis still effective to prevent low birth weight? {R}esults of a study in {B}enin - art. no. 27},
  author = {{D}enoeud, {L}ise and {F}ievet, {N}adine and {A}ubouy, {A}gn{\`e}s and {A}yemonna, {P}aul and {K}iniffo, {R}. and {M}assougbodji, {A}. and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n areas of stable transmission, malaria during pregnancy is associated with severe maternal and foetal outcomes, especially low birth weight ( {LBW}). {T}o prevent these complications, weekly chloroquine ({CQ}) chemoprophylaxis is now being replaced by intermittent preventive treatment with sulfadoxine- pyrimethamine in {W}est {A}frica. {T}he prevalence of placental malaria and its burden on {LBW} were assessed in {B}enin to evaluate the efficacy of weekly {CQ} chemoprophylaxis, prior to its replacement by intermittent preventive treatment. {M}ethods: {I}n two maternity clinics in {O}uidah, an observational study was conducted between {A}pril 2004 and {A}pril 2005. {A}t each delivery, placental blood smears were examined for malaria infection and women were interviewed on their pregnancy history including {CQ} intake and dosage. {CQ} was measured in the urine of a sub-sample (n = 166). {M}ultiple logistic and linear regression were used to assess factors associated with {LBW} and placental malaria. {R}esults: {A}mong 1090 singleton live births, prevalence of placental malaria and {LBW} were 16% and 17% respectively. {A}fter adjustment, there was a non-significant association between placental malaria and {LBW} ( adjusted {OR} = 1.43; {P} = 0.10). {M}ultiple linear regression showed a positive association between placental malaria and decreased birth weight in primigravidae. {M}ore than 98% of the women reported regular chemoprophylaxis and {CQ} was detectable in 99% of urine samples. {P}rotection from {LBW} was high in women reporting regular {CQ} prophylaxis, with a strong duration-effect relationship ( test for linear trend: {P} < 0,001). {C}onclusion: {D}espite high parasite resistance and limited effect on placental malaria, a {CQ} chemoprophylaxis taken at adequate doses showed to be still effective in reducing {LBW} in {B}enin.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  numero = {},
  pages = {{NIL}_1--{NIL}_8},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-27},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037901},
}