%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vidal, Nicole
%A Niyongabo, T.
%A Nduwimana, J.
%A Butel, Christelle
%A Ndayiragije, A.
%A Wakana, J.
%A Nduwimana, M.
%A Delaporte, Eric
%A Peeters, Martine
%T HIV type 1 diversity and antiretroviral drug resistance mutations in Burundi
%D 2007
%L fdi:010037857
%G ENG
%J Aids Research and Human Retroviruses
%@ 0889-2229
%M ISI:000243995300023
%N 1
%P 175-180
%R 10.1089/aid.2006.0126
%U https://www.documentation.ird.fr/hor/fdi:010037857
%> https://www.documentation.ird.fr/intranet/publi/2007/03/010037857.pdf
%V 23
%W Horizon (IRD)
%X In 2002, an HIV surveillance study was performed among more than 5500 individuals representing the general population of urban and rural districts in Burundi. In this report, we genetically characterized a subset of the HIV-1-positive samples identified during this survey, including all the HIV-positive samples from Bujumbura, the capital city, and samples from one semiurban and one rural district. One hundred and nineteen samples were genetically characterized in the V3-V5 region of the env gene and/or in the protease and reverse transcriptase region of the pol gene. Phylogenetic analysis of 101 env/pol sequences revealed that the HIV-1 epidemic in Burundi was driven by subtype C (81.2%), followed by subtype A (7.9%) and polC/envA recombinants (5.9%). One major mutation associated with resistance to antiretroviral drugs (ARVs) in the pol gene, as defined by the International AIDS Society Resistance Testing-USA panel, was observed in one individual, but many minor resistance-associated mutations were also present in the majority of the samples.
%$ 052