@article{fdi:010037756,
  title = {{C}an aquatic distribution of human pharmaceuticals be related to pharmacological data?},
  author = {{W}illiams, {M}. and {S}aison, {C}arine {L}. {A}. and {W}illiams, {D}. {B}. and {K}ookana, {R}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he recognition of pharmaceuticals as significant environmental contaminants has only been a recent phenomenon. {T}herefore there is a paucity of data relating to the fate and effects of pharmaceuticals once they enter an aquatic receiving system. {T}he amount of work that needs to be done in terms of risk assessment for pharmaceuticals required by regulatory agencies is substantial. {T}his paper has determined the environmental partitioning coefficient ({K}-d) of 13 diverse human pharmaceuticals in three model systems of differing combinations of solid phases and solutions. {T}he {K}-d values were then compared with distribution values of the pharmaceuticals in the human body determined from pharmacological studies. {T}his was done to assess the functional relationship between {K}d and distribution values in the human body ({VD}). {K}d values ranged from 3 to 2450 {L} kg(-1). {R}egression coefficients ranged from r(2) = 0.62-0.72, indicating that {VD} values are a useful indicator for the {K}d values of the tested pharmaceuticals within the batch sorption systems. {T}he relationship between {K}-d and {V}-{D} should therefore be further explored to determine whether this relationship can be applied to a broader range of pharmaceuticals in more diverse environmental systems. {E}xploiting available human pharmacological data in such a way would be of great benefit in prioritising human pharmaceuticals as environmental contaminants in the risk assessment process.},
  keywords = {pharmacokinetics ; fate ; batch sorption ; partitioning coefficient ; volume of distribution ; risk assessment},
  booktitle = {},
  journal = {{C}hemosphere},
  volume = {65},
  numero = {11},
  pages = {2253--2259},
  ISSN = {0045-6535},
  year = {2006},
  DOI = {10.1016/j.chemosphere.2006.05.036},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037756},
}