Telleria Jenny auteur aut IRD Lafay Bénédicte auteur aut IRD Virreira M. auteur aut IRD Barnabé Christian auteur aut IRD Tibayrenc Michel auteur aut IRD Svoboda M. auteur aut IRD text journalArticle eng text/pdf born digital access The comparisons of 170 sequences of kinetoplast DNA minicircle hypervariable region obtained from 19 stocks of Trypanosoma cruzi and 2 stocks of Trypanosoma cruzi marenkellei showed that only 56% exhibited a significant homology one with other sequences. These sequences could be grouped into homology classes showing no significant sequence similarity with any other homology group. The 44% remaining sequences thus corresponded to unique sequences in our data set. In the DTU I ("Discrete Typing Units") 51% of the sequences were unique. In contrast, in the DTU IId, 87.5% of sequences were distributed into three classes. The results obtained for T. cruzi marinkellei, showed that all sequences were unique, without any similarity between them and T. cruzi sequences. Analysis of palindromes in all sequence sets show high frequency of the EcoRI site. Analysis of repetitive sequences suggested a common ancestral origin of the kDNA. The editing mechanism that occurs in kinetoplastidae is discussed. specialized Trypanosoma cruzi minicircles kinetoplast DNA kDNA polymorphism hypervariable domain DTU Discrete Typing Units evolution editing 052 020 114 4 279-288 2006 0014-4894 https://www.documentation.ird.fr/hor/fdi:010037740 10.1016/j.exppara.2006.04.005 0014-4894 [F A010037740] https://www.documentation.ird.fr/hor/fdi:010037740 https://www.documentation.ird.fr/intranet/publi/2007/01/010037740.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2007-01-29 2017-08-23 fdi:010037740 fre