@article{fdi:010037740,
  title = {{T}rypanosoma cruzi: {S}equence analysis of the variable region of kinetoplast minicircles},
  author = {{T}elleria, {J}enny and {L}afay, {B}{\'e}n{\'e}dicte and {V}irreira, {M}. and {B}arnab{\'e}, {C}hristian and {T}ibayrenc, {M}ichel and {S}voboda, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he comparisons of 170 sequences of kinetoplast {DNA} minicircle hypervariable region obtained from 19 stocks of {T}rypanosoma cruzi and 2 stocks of {T}rypanosoma cruzi marenkellei showed that only 56% exhibited a significant homology one with other sequences. {T}hese sequences could be grouped into homology classes showing no significant sequence similarity with any other homology group. {T}he 44% remaining sequences thus corresponded to unique sequences in our data set. {I}n the {DTU} {I} ("{D}iscrete {T}yping {U}nits") 51% of the sequences were unique. {I}n contrast, in the {DTU} {II}d, 87.5% of sequences were distributed into three classes. {T}he results obtained for {T}. cruzi marinkellei, showed that all sequences were unique, without any similarity between them and {T}. cruzi sequences. {A}nalysis of palindromes in all sequence sets show high frequency of the {E}co{RI} site. {A}nalysis of repetitive sequences suggested a common ancestral origin of the k{DNA}. {T}he editing mechanism that occurs in kinetoplastidae is discussed.},
  keywords = {{T}rypanosoma cruzi ; minicircles ; kinetoplast {DNA} k{DNA} polymorphism ; hypervariable domain ; {DTU} {D}iscrete {T}yping {U}nits ; evolution ; editing},
  booktitle = {},
  journal = {{E}xperimental {P}arasitology},
  volume = {114},
  numero = {4},
  pages = {279--288},
  ISSN = {0014-4894},
  year = {2006},
  DOI = {10.1016/j.exppara.2006.04.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037740},
}