Acquisition of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes during pregnancy Fievet Nadine auteur aut IRD Le Hesran Jean-Yves auteur aut IRD Cottrell Gilles auteur aut IRD Doucoure Souleymane auteur aut IRD Diouf Ibrahima auteur aut IRD Ndiaye Jean-Louis auteur aut IRD Bertin Gwladys auteur aut IRD Gaye O. auteur aut IRD Sow S. auteur aut IRD Deloron Philippe auteur aut IRD text journalArticle eng text/pdf born digital access Pregnancy-associated malaria is characterized by Plasmodium falciparum adherence to chondroitin sulfate A (CSA) in placenta, through a particular variant surface antigen (VSA). VSA(CSA)-specific IgG are involved in protection against placental malaria. In order to assess the relationship between VSA(CSA)-specific antibody responses and parity as well as protection against placental malaria, the occurrence of P. falciparum infection was assessed in 306 pregnant women from a low malaria transmission area of Senegal. Anti-VSA(CSA) antibodies against three placental parasite isolates were measured by flow cytometry, at enrollment and delivery. Placental infection prevalence rates were highest in primigravidae, but no clear decreasing trend was observed from the second pregnancy onwards. Anti-VSA(CSA) antibody prevalence rates increased with parity. Both anti-VSA(CSA) antibody prevalence rates and levels increased during pregnancy only in women infected with P. falciparum. Although a single or a very limited number of P. falciparum infections were able to induce an anti-VSA(CSA) antibody response, the level or the quality of this response did not appear to confer protection against placental malaria infection. (c) 2006 Elsevier B.V. All rights reserved. specialized Plasmodium falciparum pregnancy malaria placenta variant surface antigen PfEMP1 052 Infection Genetics and Evolution 6 6 459-463 2006 1567-1348 https://www.documentation.ird.fr/hor/fdi:010037688 10.1016/j.meegid.2006.02.006 1567-1348 [F A010037688] https://www.documentation.ird.fr/hor/fdi:010037688 https://www.documentation.ird.fr/intranet/publi/2006/12/010037688.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2006-12-21 2017-08-23 fdi:010037688 fre