@article{fdi:010037653,
  title = {{S}imalikalactone {D} is responsible for the antimalarial properties of an amazonian traditional remedy made with {Q}uassia amara {L}. ({S}imaroubaceae)},
  author = {{B}ertani, {S}. and {H}ouel, {E}. and {S}tien, {D}. and {C}hevolot, {L}. and {J}ullian, {V}al{\'e}rie and {G}aravito, {G}. and {B}ourdy, {G}enevi{\`e}ve and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{F}rench {G}uiana ({N}orth-{E}ast {A}mazonia) records high malaria incidence rates. {T}he traditional antimalarial remedy most widespread there is a simple tea made out from {Q}uassia amara {L}. leaves ({S}imaroubaceae). {T}his herbal tea displays an excellent antimalarial activity both in vitro and in vivo. {A} known quassinoid, simalikalactone {D} ({S}k{D}), was identified as the active compound, with an {IC}50 value of 10 n{M} against {F}e{B}1 {P}lasmodium falciparum chloroquine resistant strain in vitro. {L}astly, it inhibits 50% of {P}lasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. {T}hese findings confirm the traditional use of this herbal tea. (c) 2006 {E}lsevier {I}reland {L}td. {A}ll rights reserved.},
  keywords = {antimalarial ; {Q}uassia amara ; quassinoids ; simalikalactone {D} ; traditional medicine},
  booktitle = {},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {108},
  numero = {1},
  pages = {155--157},
  ISSN = {0378-8741},
  year = {2006},
  DOI = {10.1016/j.jep.2006.04.017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037653},
}