Beaudrap Pierre de auteur aut IRD Witten G. auteur aut IRD Biltz G. auteur aut IRD Perrier Edith auteur aut IRD text journalArticle eng text/pdf born digital access Fuel selection in human muscle is key to explaining insulin resistance. in obesity and type 2 diabetes mellitus, there is an increased content of lipid within and around muscle fibers. Changes in muscle fuel partitioning of lipid, between oxidation and storage of fat, contribute to the accumulation of intramuscular triglycerides and to the pathogenesis of both obesity and type 2 diabetes mellitus. A mathematical model of the aggregated metabolism in skeletal muscle was developed and the effects of fuel selection for lean and obese individuals under fasting conditions, insulin-stimulated conditions, and oscillating insulin conditions were examined. Model results were complementary to prior observations that elevated lipid oxidation during insulin-stimulated conditions is correlated with insulin resistance. The model also adequately simulated metabolic inflexibility between fat and glucose oxidation in the obese individual. A novel sensitivity analysis indicated the strong interaction effects of parameters of glucose and lipid oxidation pathways on the variables of each pathway. (c) 2006 Elsevier Ltd. All rights reserved. specialized fuel selection skeletal muscle model insulin resistance 020 242 1 151-163 2006 0022-5193 https://www.documentation.ird.fr/hor/fdi:010037612 10.1016/j.jtbi.2006.02.009 0022-5193 [F A010037612] https://www.documentation.ird.fr/hor/fdi:010037612 https://www.documentation.ird.fr/intranet/publi/2006/10/010037612.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2006-10-06 2017-08-23 fdi:010037612 fre