@article{fdi:010037612,
  title = {{M}echanistic model of fuel selection in the muscle},
  author = {{B}eaudrap, {P}ierre de and {W}itten, {G}. and {B}iltz, {G}. and {P}errier, {E}dith},
  editor = {},
  language = {{ENG}},
  abstract = {{F}uel selection in human muscle is key to explaining insulin resistance. in obesity and type 2 diabetes mellitus, there is an increased content of lipid within and around muscle fibers. {C}hanges in muscle fuel partitioning of lipid, between oxidation and storage of fat, contribute to the accumulation of intramuscular triglycerides and to the pathogenesis of both obesity and type 2 diabetes mellitus. {A} mathematical model of the aggregated metabolism in skeletal muscle was developed and the effects of fuel selection for lean and obese individuals under fasting conditions, insulin-stimulated conditions, and oscillating insulin conditions were examined. {M}odel results were complementary to prior observations that elevated lipid oxidation during insulin-stimulated conditions is correlated with insulin resistance. {T}he model also adequately simulated metabolic inflexibility between fat and glucose oxidation in the obese individual. {A} novel sensitivity analysis indicated the strong interaction effects of parameters of glucose and lipid oxidation pathways on the variables of each pathway. (c) 2006 {E}lsevier {L}td. {A}ll rights reserved.},
  keywords = {fuel selection ; skeletal muscle ; model ; insulin resistance},
  booktitle = {},
  journal = {{J}ournal of {T}heoretical {B}iology},
  volume = {242},
  numero = {1},
  pages = {151--163},
  ISSN = {0022-5193},
  year = {2006},
  DOI = {10.1016/j.jtbi.2006.02.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037612},
}