@article{fdi:010037601,
  title = {{P}lasmodium falciparum genotype population dynamics in asymptomatic children from {S}enegal},
  author = {{J}afari {G}uemouri, {S}ayeh and {B}oudin, {C}hristian and {F}ievet, {N}adine and {N}diaye, {P}ape and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n areas where malaria is endemic, infected individuals generally harbor a mixture of genetically distinct {P}lasmodium falciparum parasite populations. {F}or the first time, we studied temporal variations of blood parasite densities and circulating genotypes in asymptomatic {S}enegalese children, at time intervals as short as 4-12 h. {T}wenty-one {S}enegalese children, presenting with an asymptomatic {P}. falciparum infection, were sampled eight times within three days. {P}arasite density was assessed by thick blood smears, and all infecting genotypes were quantified by the fragment-analysis method. {P}arasite densities showed dramatic fluctuations up to a 1 to 1000 ratio, with at least one peak of parasite density. {P}olyclonal infections were detected in all children, with a multiplicity of infection of 5.2-6.8 genotypes per child. {A} single sample never reflected the full complexity of the parasite populations hosted by a given individual. {G}enotypes with different behaviors were detected in all children, some genotypes undergoing major fluctuations, while others were highly stable during the follow-up. {A} single peripheral blood sampling does not reflect the total parasite load. {R}epeated sampling is needed to have a more detailed scheme of parasite population dynamics and a better knowledge of the true complexity of an infection. (c) 2006 {E}lsevier {SAS}. {A}ll rights reserved.},
  keywords = {{P}lasmodium falciparian ; asymptomatic individuals ; fluctuations ; dynamics},
  booktitle = {},
  journal = {{M}icrobes and {I}nfection},
  volume = {8},
  numero = {7},
  pages = {1663--1670},
  ISSN = {1286-4579},
  year = {2006},
  DOI = {10.1016/j.micinf.2006.01.023},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037601},
}