@article{fdi:010036717,
  title = {{F}actors associated with adverse reactions induced by caprylic acid-fractionated whole {I}g{G} preparations : comparison between horse, sheep and camel {I}g{G}s},
  author = {{H}errera, {M}. and {L}eon, {G}. and {S}egura, {A}. and {M}eneses, {F}. and {L}omonte, {B}. and {C}hippaux, {J}ean-{P}hilippe and {G}utierrez, {J}.{M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}aprylic acid purification of {I}g{G}, currently used in the manufacture of horse-derived antivenoms, was successfully adapted for the preparation of sheep and camel {I}g{G}. {S}heep {I}g{G} had a molecular mass of similar to 150 k{D}a, whereas camel {I}g{G} presented two bands of molecular masses of similar to 160 and 100 k{D}a, the latter corresponding to heavy-chain {I}g{G}, which is devoid of light chains. {H}orse, sheep and camel {I}g{G}s were compared by several parameters aiming at predicting their potential for induction of early and late adverse reactions. {H}orse and sheep {I}g{G}s showed a higher anticomplementary activity than camel {I}g{G}, and also elicited a higher anti-{I}g{G} response than camel {I}g{G}, when injected in mice. {H}orse {I}g{G} agglutinated human type {O}+ erythrocytes, whereas no such reactivity was observed in sheep and camel {I}g{G} preparations. {A} novel procedure was used for the detection of antibodies in human serum against animal {I}g{G}s. {I}t was found that a pool of human sera collected in {C}osta {R}ica had a higher titer of antibodies directed against horse and sheep {I}g{G}s than against camel {I}g{G}. {O}verall, camel {I}g{G} showed the lowest potential for the induction of adverse reactions among the three {I}g{G}s tested. (c) 2005 {E}lsevier {L}td. {A}ll rights, reserved.},
  keywords = {{I}g{G} ; caprylic acid ; anticomplementary activity ; antivenom ; adverse reactions ; anti {I}g{G} antibodies},
  booktitle = {},
  journal = {{T}oxicon},
  volume = {46},
  numero = {7},
  pages = {775--781},
  ISSN = {0041-0101},
  year = {2005},
  DOI = {10.1016/j.toxicon.2005.08.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010036717},
}