@article{fdi:010035759,
  title = {{D}evelopment of cellular immune responses to {P}lasmodium falciparum blood stage antigens from birth to 36 months of age in {C}ameroon},
  author = {{L}e {H}esran, {J}ean-{Y}ves and {F}i{\'e}vet, {N}adine and {T}hioulouse, {J}. and {P}ersonne, {P}. and {M}aubert, {B}. and {M}' bidias, {S}. and {E}tye' ale, {D}. and {C}ot, {M}ichel and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{N}aturally acquired immunity to {P}lasmodium falciparum is related to immune system that changes during normal development and ageing. {T}he effects of repeated infections during the early life on the maturation of the immune system are still unknown. {E}lucidation of these effects is of considerable interest given that malaria originates high mortality, especially during the first years of life. {W}e conducted a cohort study to identify naturally acquired immune responses to {P}. falciparum. {C}ellular responses of {C}ameroonian neonates from birth to 36 months of age were evaluated every 6 months by cell proliferation and cytokines ({IFN}-gamma, {IL}-2 and {IL}-4) production after in vitro culture in the presence of schizont extract and {P}f155/{RESA} peptides. {D}ata were analyzed by a multiple correspondence analysis ({MCA}) exhibiting three main findings. {F}irstly, the lack of time-dependant evolution of specific immune pathways recruitment in the response to a given antigen, no antigen inducing a specific mode of response at a given time-point. {S}econdly, most of the data variability was expressed by {IFN}-gamma and {IL}-4 productions, and the major variation of the immune response with age involved this change in {IFN}-gamma production. {T}hirdly, the age-related immune response evolution is characterized by the acquisition of the capacity to mount a {IFN}-gamma response, a transient phase during which children produce a high {IL}-4 response, and the fast vanishing of the dominance of the {IL}-2 response. {T}hese results suggest that {P}. falciparum specific immune responses are first oriented towards a {T}h2-type of response, and later switch to {T}h1-type of response. (c) 2006 {E}lsevier {B}.{V}. {A}ll rights reserved.},
  keywords = {{P}lasmodium falciparum ; children ; cytokines ; immunity},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {98},
  numero = {3},
  pages = {261--269},
  ISSN = {0001-706{X}},
  year = {2006},
  DOI = {10.1016/j.actatropica.2006.05.010},
  URL = {https://www.documentation.ird.fr/hor/fdi:010035759},
}