@article{fdi:010035748, title = {{T}ransmission and immunity: the importance of heterogeneity in the fight against malaria}, author = {{F}ilion, {G}.{J}.{P}. and {P}aul, {R}.{E}.{L}. and {R}obert, {V}incent}, editor = {}, language = {{ENG}}, abstract = {{T}he complex relationship between transmission and parasite prevalence in humans is an important issue. {U}sing a large dataset matching estimates of malaria transmission and {P}lasmodium falciparum prevalence in {A}frican children, a stimulating study published in {N}ature provides evidence that heterogeneity in susceptibility crucially determines the prevalence of infection. {M}oreover, it suggests that children who clear infections are not immune to new infections, irrespective of the amount of transmission. {I}t is important to question the relevance of such results based on mathematical models when discussing host-parasite interactions, especially their implications for public health interventions.}, keywords = {{AFRIQUE} {SUBSAHARIENNE}}, booktitle = {}, journal = {{T}rends in {P}arasitology}, volume = {22}, numero = {8}, pages = {345--348}, ISSN = {1471-4922}, year = {2006}, DOI = {10.1016/j.pt.2006.06.005}, URL = {https://www.documentation.ird.fr/hor/fdi:010035748}, }