Keele B. F. auteur aut IRD Van Heuverswyn F. auteur aut IRD Li Y.Y. auteur aut IRD Bailes E. auteur aut IRD Takehisa J. auteur aut IRD Santiago M. L. auteur aut IRD Bibollet Ruche F. auteur aut IRD Chen Y. L. auteur aut IRD Wain L. V. auteur aut IRD Liégeois Florian auteur aut IRD Loul S. auteur aut IRD Mpoudi Ngolé E. auteur aut IRD Bienvenue Y. auteur aut IRD Delaporte Eric auteur aut IRD Brookfield J. F. Y. auteur aut IRD Sharp P. M. auteur aut IRD Shaw G. M. auteur aut IRD Peeters Martine auteur aut IRD Hahn B. H. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome ( AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus ( SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P.t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic ( group M) and nonpandemic ( group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1. specialized 052 313 5786 523-526 2006 0036-8075 https://www.documentation.ird.fr/hor/fdi:010035725 10.1016/j.jep.2005.12.022 0036-8075 [F B010035725] https://www.documentation.ird.fr/hor/fdi:010035725 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-01/010035725.pdf IRD - Base Horizon / Pleins textes 2006-08-30 2025-01-03 fdi:010035725 fre