%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Keele, B. F.
%A Van Heuverswyn, F.
%A Li, Y.Y.
%A Bailes, E.
%A Takehisa, J.
%A Santiago, M. L.
%A Bibollet Ruche, F.
%A Chen, Y. L.
%A Wain, L. V.
%A Liégeois, Florian
%A Loul, S.
%A Mpoudi Ngolé, E.
%A Bienvenue, Y.
%A Delaporte, Eric
%A Brookfield, J. F. Y.
%A Sharp, P. M.
%A Shaw, G. M.
%A Peeters, Martine
%A Hahn, B. H.
%T Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
%D 2006
%L fdi:010035725
%G ENG
%J Science
%@ 0036-8075
%M CC:0002393086-0063
%N 5786
%P 523-526
%R 10.1016/j.jep.2005.12.022
%U https://www.documentation.ird.fr/hor/fdi:010035725
%> https://www.documentation.ird.fr/intranet/publi/2006/08/010035725.pdf
%V 313
%W Horizon (IRD)
%X Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome ( AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus ( SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P.t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic ( group M) and nonpandemic ( group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.
%$ 052