@article{fdi:010035639,
  title = {{R}evisiting the role of neutralizing antibodies in mother-to-child transmission of {HIV}-1},
  author = {{B}arin, {F}. and {J}ourdain, {G}onzague and {B}runet, {S}. and {N}go {G}iang {H}uong, {N}icole and {W}eerawatgoompa, {S}. and {K}arnchanamayul, {W}. and {A}riyadej, {S}. and {H}ansudewechakul, {R}. and {A}chalapong, {J}. and {Y}uthavisuthi, {P}. and {N}gampiyaskul, {C}. and {B}hakeecheep, {S}. and {H}emwutthiphan, {C}. and {L}allemant, {M}arc},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e analyzed the association between mother-to-child transmission ({MTCT}) of human immunodeficiency virus type 1 ({HIV}-1) and maternal neutralizing antibodies to heterologous primary isolates of various {HIV}-1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing activity. {O}ur study sample included 90 {T}hai women for whom the timing of {HIV}-1 transmission ( in utero or intrapartum) was known. {T}he statistical analysis included a conditional logistic-regression model to control for both plasma viral load and duration of zidovudine prophylaxis. {T}he higher the titer of neutralizing antibodies to a heterologous strain of the same clade, the lower the rate of {MTCT} of {HIV}-1. {M}ore specifically, high levels of neutralizing antibodies to the {MBA} ({CRF}01_{AE}) strain were associated with low intrapartum transmission of {HIV}-1. {T}his suggested that such heterologous neutralizing antibodies may be involved in the natural prevention of late perinatal {HIV} transmission. {T}hese data are consistent with the hypothesis that the use of some antibodies might help to prevent perinatal {HIV} transmission, through passive immunoprophylaxis. {M}oreover, the study of humoral factors associated with {MTCT} of {HIV}-1 may identify correlates of protection that should help in the design of efficient {HIV}/acquired immunodeficiency syndrome vaccines.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {193},
  numero = {11},
  pages = {1504--1511},
  ISSN = {0022-1899},
  year = {2006},
  DOI = {10.1086/503778},
  URL = {https://www.documentation.ird.fr/hor/fdi:010035639},
}