%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Courtin, David
%A Jamonneau, Vincent
%A Mathieu, J.F.
%A Koffi, M.
%A Milet, J.
%A Yeminanga, Claude Sese
%A Kumeso, V.K.B.
%A Cuny, Gérard
%A Bilengue, C.M.M.
%A Garcia, André
%T Comparison of cytokine plasma levels in human African trypanosomiasis
%D 2006
%L fdi:010035631
%G ENG
%J Tropical Medicine and International Health
%@ 1360-2276
%K gamma interferon ; human African trypanosomiasis ; interleukin ; Trypanosoma brucei gambiense ; tumour necrosis factor alpha
%K AFRIQUE SUBSAHARIENNE
%K REPUBLIQUE DEMOCRATIQUE DU CONGO
%M CC:0002370978-0011
%N 5
%P 647-653
%R 10.1111/j.1365-3156.2006.01612.x
%U https://www.documentation.ird.fr/hor/fdi:010035631
%> https://www.documentation.ird.fr/intranet/publi/2006/05/010035631.pdf
%V 11
%W Horizon (IRD)
%X Background: Immunological studies suggest that human African trypanosomiasis (HAT) is associated with inflammatory responses. A better understanding of the complex cytokine interactions regulating HAT infections is essential to elucidate the mechanisms of generalized immunosuppression. Method: We determined levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma protein levels in plasma samples from three groups of individuals from the Democratic Republic of Congo: (i) HAT cases; (ii) seropositive individuals for whom parasite detection was negative and (ii) controls. Results: Plasma levels of six cytokines were significantly higher in HAT cases than in both controls (P < 0.003) and seropositive individuals (P < 0.016). IL-2 and IL-10 concentrations were significantly lower (P < 0.02) in the seropositive group than in the control one. Conclusion: Human African trypanosomiasis leads to the development of strong cytokine responses, indicating the potential involvement of IL-2 and IL-10 in the phenomenon of seropositivity without parasitological confirmation. This strongly suggests the involvement of immunity in this particular aspect of HAT epidemiology.
%$ 052