@article{fdi:010035629,
  title = {{D}etection of trypanosome-specific antibodies in saliva, towards non-invasive serological diagnosis of sleeping sickness},
  author = {{L}ejon, {V}. and {J}amonneau, {V}incent and {S}olano, {P}hilippe and {A}tchade, {P}. and {M}umba, {D}. and {N}koy, {N}. and {B}ebronne, {N}. and {K}ibonja, {T}. and {B}alharbi, {F}. and {W}ierckx, {A}. and {B}oelaert, {M}. and {B}uscher, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}he detection of trypanosome-specific antibodies in saliva is technically feasible, and, if clinically validated, could become an attractive option for non-invasive diagnosis of sleeping sickness. {W}e wanted to optimize the test format of an enzyme-linked immunosorbent assay ({ELISA})-based antibody detection system. {M}ethods: {D}ifferent {ELISA} formats for antibody detection in serum and saliva were developed and standardized. {S}aliva and serum samples were collected from 78 patient and 128 endemic control samples, and sensitivity and specificity of saliva {ELISA}s, serum {ELISA}s and the card agglutination test for trypanosomiasis ({CATT}), were evaluated. {R}esults: {A}ll {ELISA} formats showed sensitivity and specificity above 90%. {S}aliva {ELISA}s showed a similar test performance as serum {ELISA}s and the {CATT} on whole blood or serum. {C}onclusions: {T}his study confirms the potential of trypanosome-specific antibody detection in saliva.},
  keywords = {human {A}frican trypanosomiasis ; antibody detection ; saliva ; serum ; diagnosis ; {T}rypanosoma brucei gambiense},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {11},
  numero = {5},
  pages = {620--627},
  ISSN = {1360-2276},
  year = {2006},
  DOI = {10.1111/j.1365-3156.2006.01620.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010035629},
}