Eftekhari M.H. auteur aut IRD Simondon Kirsten auteur aut IRD Jalali M. auteur aut IRD Keshavarz S.A. auteur aut IRD Elguero Eric auteur aut IRD Eshraghian M.R. auteur aut IRD Saadat N. auteur aut IRD text journalArticle eng text/pdf born digital access Objective: To investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls. Design: A double-blind randomized intervention study. Setting: The study was performed from 2002 through 2003 in the Islamic Republic of Iran. Subjects: 103 iron-deficient non-anaemic girls who fulfilled all inclusion criteria were included, and 94 subjects successfully completed the study. Interventions: Patients were randomly assigned to one of four groups and treated with a single oral dose of 190 mg iodine plus 300 mg ferrous sulphate 5 times/week (n = 24), 300 mg ferrous sulphate 5 times/week (n = 23), a single oral dose of 190 mg iodine ( n 25), or a placebo ( n 22) for 12 weeks. Results: All groups were comparable at baseline. After the intervention, there was a significant increase in ferritin and transferrin saturation in the iron + iodine group (17.6 vs 8.7 mu g/dl, and 18.8 vs 7.2%, respectively, P<0.001 for both) and in the iron group (P<0.001 for both). Urinary iodine doubled in the iron + iodine group and in the iodine group ( P<0.001 for both). Thyroid indices tT4, tT3 and T3RU increased and reverse RT3 decreased in the iron + iodine group ( 10 vs 8.9 mu g/dl, P< 0.001; 143 vs 138 mu g/dl, P<0.05; 32.3 vs 28.4%, P<0.001 and 24.8 vs 44.2 ng/dl, P<0.001, respectively) and in the iron group. These two groups did not differ for any of the four indices, but both differed significantly from the iodine and placebo groups. Conclusions: Our results indicate that improvement of iron status was accompanied by an improvement in some indices of thyroid hormones. specialized FER ANEMIE DEFICIENCE SUPPLEMENTATION HORMONE ADOLESCENT CONSOMMATION ALIMENTAIRE ANALYSE STATISTIQUE ETUDE COMPARATIVE IODE FERRITINE GLANDE THYROIDE SULFATE DE FER iron ferritin thyroid hormones supplementation trial micronutrients IRAN 054PHYMED02 60 4 545-552 2006 0954-3007 https://www.documentation.ird.fr/hor/fdi:010035615 10.1038/sj.ejcn.1602349 0954-3007 [F B010035615] https://www.documentation.ird.fr/hor/fdi:010035615 https://www.documentation.ird.fr/intranet/publi/2006/05/010035615.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2006-05-30 2017-08-23 fdi:010035615 fre