@article{fdi:010035615,
  title = {{E}ffects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent {I}ranian girls},
  author = {{E}ftekhari, {M}.{H}. and {S}imondon, {K}irsten and {J}alali, {M}. and {K}eshavarz, {S}.{A}. and {E}lguero, {E}ric and {E}shraghian, {M}.{R}. and {S}aadat, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o investigate whether iron supplementation can improve thyroid hormone function in iron-deficient adolescent girls. {D}esign: {A} double-blind randomized intervention study. {S}etting: {T}he study was performed from 2002 through 2003 in the {I}slamic {R}epublic of {I}ran. {S}ubjects: 103 iron-deficient non-anaemic girls who fulfilled all inclusion criteria were included, and 94 subjects successfully completed the study. {I}nterventions: {P}atients were randomly assigned to one of four groups and treated with a single oral dose of 190 mg iodine plus 300 mg ferrous sulphate 5 times/week (n = 24), 300 mg ferrous sulphate 5 times/week (n = 23), a single oral dose of 190 mg iodine ( n 25), or a placebo ( n 22) for 12 weeks. {R}esults: {A}ll groups were comparable at baseline. {A}fter the intervention, there was a significant increase in ferritin and transferrin saturation in the iron + iodine group (17.6 vs 8.7 mu g/dl, and 18.8 vs 7.2%, respectively, {P}<0.001 for both) and in the iron group ({P}<0.001 for both). {U}rinary iodine doubled in the iron + iodine group and in the iodine group ( {P}<0.001 for both). {T}hyroid indices t{T}4, t{T}3 and {T}3{RU} increased and reverse {RT}3 decreased in the iron + iodine group ( 10 vs 8.9 mu g/dl, {P}< 0.001; 143 vs 138 mu g/dl, {P}<0.05; 32.3 vs 28.4%, {P}<0.001 and 24.8 vs 44.2 ng/dl, {P}<0.001, respectively) and in the iron group. {T}hese two groups did not differ for any of the four indices, but both differed significantly from the iodine and placebo groups. {C}onclusions: {O}ur results indicate that improvement of iron status was accompanied by an improvement in some indices of thyroid hormones.},
  keywords = {{FER} ; {ANEMIE} ; {DEFICIENCE} ; {SUPPLEMENTATION} ; {HORMONE} ; {ADOLESCENT} ; {CONSOMMATION} {ALIMENTAIRE} ; {ANALYSE} {STATISTIQUE} ; {ETUDE} {COMPARATIVE} ; {IODE} ; {FERRITINE} ; {GLANDE} {THYROIDE} ; {SULFATE} {DE} {FER} ; iron ; ferritin ; thyroid hormones ; supplementation trial ; micronutrients ; {IRAN}},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {C}linical {N}utrition},
  volume = {60},
  numero = {4},
  pages = {545--552},
  ISSN = {0954-3007},
  year = {2006},
  DOI = {10.1038/sj.ejcn.1602349},
  URL = {https://www.documentation.ird.fr/hor/fdi:010035615},
}