@article{fdi:010035601,
  title = {{I}nterest of tumor necrosis factor-alpha-308 {G}/{A} and interleukin-10-592 {C}/{A} polymorphisms in human {A}frican trypanosomiasis},
  author = {{C}ourtin, {D}avid and {A}rgiro, {L}. and {J}amonneau, {V}incent and {N}'{D}ri, {L}. and {N}'{G}uessan, {P}. and {A}bel, {L}. and {D}essein, {A}. and {C}ot, {M}ichel and {L}aveissi{\`e}re, {C}laude and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study aimed to determine whether single nucleotide polymorphisms ({SNP}s) within tumour necrosis factor-alpha ({TNF}) and interleukin-10 (100) promoters and genes are associated with human {A}frican trypanosomiasis ({HAT}). {T}he polymorphisms used in the analysis were {TNF}-308 {G}/{A},. {TNF}-238 {G}/{A}, {TNF}-1031 {T}/{C}, {TNF}+488 ({G}/{A}), {IL}10(-1082 {G}/{A}) and {IL}10(-592 {C}/{A}). {A} familial case-control sample of 277 individuals ( 102 cases and 175 parents) and a matched case-control group of 225 subjects (88 cases and 137 unrelated controls) were gathered together in this study. {A} conditional logistic regression was used to test for association. {W}e carried {O}ut this analysis in the overall population and after stratification by time of exposure, age and ethnic group. {O}ur results show that in the overall {P}opulation, and after stratification by time of exposure, the {IL}10(-592) ({A}) allele is associated with a lower risk of disease, suggesting the possibility of a protective effect. {A}fter stratification by time of exposure, individuals homozygous for the {SNP} located in the {TNF}-308 promoter were shown to present a higher risk of developing the disease early after exposure. {O}ur study shows that {TNF}-308 ({G}/{A}) and {IL}10(-592) ({C}/{A}) {SNP}s are polymorphisms of interest in the investigation of the genetic susceptibility to human {A}frican trypanosomiasis. {L}arger studies are currently underway to confirm these results. (c) 2005 {E}lsevier {B}.{V}. {A}ll rights reserved.},
  keywords = {association study ; human {A}frican trypanosomiasis ; sleeping sickness ; {IL}10 ; {TNF} ; {T}rypanosoma brucei gambiense ; genetic susceptibility},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {6},
  numero = {2},
  pages = {123--129},
  ISSN = {1567-1348},
  year = {2006},
  DOI = {10.1016/j.meegid.2005.03.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010035601},
}