@article{fdi:010034521,
  title = {{A}ntibodies to the conserved {C}-terminal domain of the {P}lasmodium falciparum merozoite surface protein 1 and to the merozoite extract and their relationship with in vitro inhibitory antibodies and protection against clinical malaria in a {S}enegalese village},
  author = {{P}erraut, {R}. and {M}arrama, {L}. and {D}iouf, {B}. and {S}okhna, {C}. and {T}all, {A}. and {N}abeth, {P}. and {T}rape, {J}ean-{F}rancois and {L}ongacre, {S}. and {M}ercereau-{P}uijalon, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ntibodies to {P}lasmodium falciparum {C}-terminal merozoite surface protein 1 ({P}f{MSP}-1p19) have been correlated with protection against malaria, but this association may apply to many merozoite antigens. {T}o address this question, we conducted a prospective serological study of 205 individuals in an active 5-month clinical survey in a {S}enegalese village where malaria is mesoendemic. {B}efore the 2000 rainy season, antibody responses specific for recombinant baculovirus {P}f{MSP}-1p19 or merozoite extracts were compared with 2 in vitro functional antibody activities (inhibition of parasite grown and erythrocyte invasion) and with the number of clinical episodes during 5 months of follow-up. {A}ntibody levels to {P}f{MSP}-1p19 and merozoite extract correlated, respectively, with erythrocyte invasion and parasite growth inhibition. {A}lthough antibody levels to both antigen preparations were associated with age, functional parameters were not. {H}igh levels of anti-{P}f{MSP}-1p19 immunoglobulin {G} were associated with reduced malaria in an age-adjusted multivariate analysis. {T}hese results support baculovirus {P}f{MSP}-1p19-based vaccine development},
  keywords = {{PALUDISME} ; {PARASITE} ; {VACCINATION} ; {ANTICORPS} ; {SEROLOGIE} ; {VILLAGE} ; {GROUPE} {D}'{AGE} ; {EXPERIMENTATION} {IN} {VITRO} ; {ANALYSE} {MULTIVARIABLE} ; {ETUDE} {COMPARATIVE} ; {TEST} {ELISA} ; {ANALYSE} {DE} {COHORTES} ; {IMMUNOGLOBULINE} {G} ; {SENEGAL} ; {NDIOP}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {191},
  numero = {2},
  pages = {264--271},
  ISSN = {0022-1899},
  year = {2005},
  DOI = {10.1086/426398},
  URL = {https://www.documentation.ird.fr/hor/fdi:010034521},
}