@article{fdi:010034500,
  title = {{I}nfluence of chemotherapy on the {P}lasmodium gametocyte sex ratio of mice and humans},
  author = {{T}alman, {A}.{M}. and {P}aul, {R}.{E}.{L}. and {S}okhna, {C}.{S}. and {D}omarle, {O}. and {A}riey, {F}. and {T}rape, {J}ean-{F}rancois and {R}obert, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium species, the etiologic agents of malaria, are obligatory sexual organisms. {G}ametocytes, the precursors of gametes, are responsible for parasite transmission from human to mosquito. {T}he sex ratio of gametocytes has been shown to have consequences for the success of this shift from vertebrate host to insect vector. {W}e attempted to document the effect of chemotherapy on the sex ratio of two different {P}lasmodium species: {P}lasmodium falciparum in children from endemic area with uncomplicated malaria treated with chloroquine ({CQ}) or sulfadoxine-pyrimethamine ({SP}), and {P}. vinckei petteri in mice treated with {CQ} or untreated. {T}he studies involved 53 patients without gametocytes at day 0 (13 {CQ} and 40 {SP}) followed for 14 days, and 15 mice (10 {CQ} and 5 controls) followed for five days. {D}uring the course of infection, a positive correlation was observed between the time of the length of infection and the proportion of male gametocytes in both {P}lasmodium species. {N}o effects of treatment ({CQ} versus {SP} for {P}. falciparum or {CQ} versus controls for {P}. vinckei petteri) on the gametocyte sex ratio were found for either {P}lasmodium species. {T}his indicates that parasites do not respond to chemotherapy by altering their sex allocation strategy, even though, in the case of {P}. falciparum, they apparently increase their overall investment in sexual stages. {T}his suggests that malaria parasite species respond to different environmental cues for their sex differentiation and sex determination.},
  keywords = {{PALUDISME} ; {PARASITE} ; {TRANSMISSION} ; {INFECTION} ; {ENFANT} ; {MEDICAMENT} ; {EFFICACITE} ; {SEX} {RATIO} ; {ANALYSE} {STATISTIQUE} ; {ETUDE} {COMPARATIVE} ; {GAMETOCYTE} ; {CHIMIOTHERAPIE} ; {CHLOROQUINE} ; {SULFADOXINE} {PYRIMETHAMINE} ; {SENEGAL} ; {DIOHINE}},
  booktitle = {},
  journal = {{T}he {A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {71},
  numero = {6},
  pages = {739--744},
  ISSN = {0002-9637},
  year = {2004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010034500},
}