@article{fdi:010027506,
  title = {{G}ametocytaemia in {S}enegalese children with uncomplicated {F}alciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine},
  author = {{S}okhna, {C}heikh-{S}adibou and {T}rape, {J}ean-{F}ran{\c{c}}ois and {R}obert, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium falciparum gametocytaemia was studied in 266 {S}enegalese children (median 4 years, range 0.5-16) with uncomplicated malaria treated with chloroquine ({CQ}), amodiaquine ({AQ}) or sulfadoxine + pyrimethamine ({SP}). {T}he proportion of resistant infections in vivo to these drugs was 44%, 16% and 7%, respectively. {G}ametocytes were counted by microscopy in thick smears on days 0, 4, 7 and 14 after treatment. {T}here was a peak of gametocytaemia one week after treatment; on days 0, 7 and 14 the gametocyte prevalences were 35%, 73% and 63%, and the geometric means of gametocyte densities were 1.3, 12.5 and 5.6/microliter of blood. {T}hree factors were found to influence gametocytaemia: treatment, efficacy of treatment, and duration of symptoms before treatment. {G}ametocyte prevalence and density significantly appeared higher in children treated with {SP} than with {CQ}, and higher with {CQ} than with {AQ}. {G}ametocyte prevalence and density were higher in resistant than in sensitive infections. {T}he period between the appearance of the first clinical symptoms and treatment was positively and significantly linked to gametocyte prevalence and density on days 0 and 4. {E}arly treatment with {AQ}, against sensitive infection, was followed by the lowest gametocytaemia. {B}y contrast, treatment with {SP} against resistant infection was followed by the highest gametocytaemia. {N}o clear relationship was observed between the density of asexual stages on day 0 and the gametocytaemia at any day between days 0 and 14. {T}he epidemiological significance of post-therapeutic gametocytaemia and its possible role in the spread of resistant parasites are underlined. {S}olutions are proposed in order to avoid or reduce this gametocytaemia.},
  keywords = {{PALUDISME} ; {TRAITEMENT} {MEDICAL} ; {MEDICAMENT} ; {ENFANT} {D}'{AGE} {SCOLAIRE} ; {SENSIBILITE} {RESISTANCE} ; {EFFICACITE} ; {ETUDE} {COMPARATIVE} ; {CHLOROQUINE} ; {AMODIAQUINE} ; {SULFADOXINE} ; {PYRIMETHAMINE} ; {GAMETOCYTE} ; {SENEGAL}},
  booktitle = {},
  journal = {{P}arasite},
  volume = {8},
  numero = {},
  pages = {243--250},
  ISSN = {1252-607{X}},
  year = {2001},
  URL = {https://www.documentation.ird.fr/hor/fdi:010027506},
}