@article{fdi:010025672,
  title = {{D}ating the common ancestor of {SIV}cpz and {HIV}-1 group {M} and the origin of {HIV}-1 subtypes by using a new method to uncover clock-like molecular evolution},
  author = {{S}alemi, {M}. and {S}trimmer, {K}. and {H}all, {W}.{W}. and {D}uffy, {M}. and {D}elaporte, {E}ric and {M}boup, {S}. and {P}eeters, {M}artine and {V}andamme, {A}.{M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ttempts to estimate the time of origin of human immunodeficiency virus ({HIV})-1 by using phylogenetic analysis are seriously flawed because of the unequal evolutionary rates among different viral lineages. {H}ere, we report a new method of molecular clock analysis, called {S}ite {S}tripping for {C}lock {D}etection ({SSCD}), which allows selection of nucleotide sites evolving at an equal rate in different lineages. {T}he method was validated on a dataset of patients all infected with hepatitis {C} virus in 1977 by the same donor, and it was able to date exactly the 'known' origin of the infection. {U}sing the same method, we calculated that the origin of {HIV}-1 group {M} radiation was in the 1930s. {I}n addition, we show that the coalescence time of the simian ancestor of {HIV}-1 group {M} and its closest related cpz strains occurred around the end of the 17th century, a date that could be considered the upper limit ot the time of simian-to-human transmission of {HIV}-1 group {M}. {T}he results show also that {SSCD} is an easy-to-use method of general applicability in molecular evolution to calibrate clock-like phylogenetic trees. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {VIRUS} ; {PHYLOGENIE} ; {METHODE} {D}'{ANALYSE} ; {EVOLUTION} ; {DIVERGENCE} ; {SSCD}.{STRIPPING} {FOR} {CLOCK} {DETECTION} ; {VIH} 1 {GROUPE} {M} ; {TRANSMISSION} {INTERSPECIFIQUE}},
  booktitle = {},
  journal = {{FASEB} {J}ournal},
  numero = {},
  pages = {16},
  ISSN = {0892-6638},
  year = {2000},
  URL = {https://www.documentation.ird.fr/hor/fdi:010025672},
}