Immune response to #Plasmodium falciparum$ liver stage antigen-1 : geographical variations within Central Africa and their relationship with protection from clinical malaria Migot Nabias F. auteur aut IRD Deloron Philippe auteur aut IRD Ringwald Pascal auteur aut IRD Dubois B. auteur aut IRD Mayombo J. auteur aut IRD Minh T.N. auteur aut IRD Fievet Nadine auteur aut IRD Millet P. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Two populations of schoolchildren from Gabon and Cameroon were tested in 1995 for their immunological reactivity to synthetic peptides (LSA-Rep, LSA-J and LSA-CTL) from Plasmodium falciparum liver stage antigen-1 (LSA-1). The prevalence and levels of both cellular (lymphocyte proliferation, tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and interleukin-10 (IL-10)) and humoral (immunoglobulin G) responses were determined. Protection from clinical malaria, determined after a prospective 1 year study in both sites, was associated with elevated proliferative responses to LSA-Rep and LSA-CTL in the Gabonese children, as well as with higher antibody levels to both schizont extract and LSA-Rep. The prevalence of peptide-stimulated TNF-alpha secretion was higher in the Cameroonian group, but higher levels of antibodies to LSA-Rep and LSA-J were found in the Gabonese children. The immunological differences observed between children in the 2 study sites are discussed in the context of both epidemiological and individual host factors. (Résumé d'auteur) specialized PALUDISME IMMUNOLOGIE ENFANT D'AGE SCOLAIRE VACCINATION ANTIGENE TEST ELISA ANTICORPS ANALYSE STATISTIQUE ETUDE REGIONALE ETUDE COMPARATIVE LSA1.LIVER STAGE ANTIGEN 1 TNF ALPHA.TUMOR NECROSIS FACTOR ALPHA IFN GAMMA.INTERFERON GAMMA IL10.INTERLEUKIN 10 LPA.LYMPHOCYTE PROLIFERATIVE ASSAY CYTOKINE CELLULE T CAMEROUN GABON 052ANOPAL04 Transactions of the Royal Society of Tropical Medicine and Hygiene 94 5 557-562 2000 0035-9203 https://www.documentation.ird.fr/hor/fdi:010024068 10.1016/S0035-9203(00)90086-5 0035-9203 [F B010024068] https://www.documentation.ird.fr/hor/fdi:010024068 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_57-58/010024068.pdf IRD - Base Horizon / Pleins textes 2001-02-06 2021-05-20 fdi:010024068 fre