Horizon 1 1 17 ACLN : Articles dans des revues avec comité de lecture non répertoriées par l'AERES Transactions of the Royal Society of Tropical Medicine and Hygiene 557-562 PALUDISME IMMUNOLOGIE ENFANT D'AGE SCOLAIRE VACCINATION ANTIGENE TEST ELISA ANTICORPS ANALYSE STATISTIQUE ETUDE REGIONALE ETUDE COMPARATIVE LSA1.LIVER STAGE ANTIGEN 1 TNF ALPHA.TUMOR NECROSIS FACTOR ALPHA IFN GAMMA.INTERFERON GAMMA IL10.INTERLEUKIN 10 LPA.LYMPHOCYTE PROLIFERATIVE ASSAY CYTOKINE CELLULE T CAMEROUN GABON DIENGA POUMA 2000 fdi:010024068 ENG Transactions of the Royal Society of Tropical Medicine and Hygiene 0035-9203 5 10.1016/S0035-9203(00)90086-5 https://www.documentation.ird.fr/hor/fdi:010024068 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_57-58/010024068.pdf 94 Horizon (IRD) Two populations of schoolchildren from Gabon and Cameroon were tested in 1995 for their immunological reactivity to synthetic peptides (LSA-Rep, LSA-J and LSA-CTL) from #Plasmodium falciparum$ liver stage antigen-1 (LSA-1). The prevalence and levels of both cellular (lymphocyte proliferation, tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and interleukin-10 (IL-10)) and humoral (immunoglobulin G) responses were determined. Protection from clinical malaria, determined after a prospective 1 year study in both sites, was associated with elevated proliferative responses to LSA-Rep and LSA-CTL in the Gabonese children, as well as with higher antibody levels to both schizont extract and LSA-Rep. The prevalence of peptide-stimulated TNF-alpha secretion was higher in the Cameroonian group, but higher levels of antibodies to LSA-Rep and LSA-J were found in the Gabonese children. The immunological differences observed between children in the 2 study sites are discussed in the context of both epidemiological and individual host factors. (Résumé d'auteur) 052ANOPAL04