%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Migot Nabias, F.
%A Deloron, Philippe
%A Ringwald, Pascal
%A Dubois, B.
%A Mayombo, J.
%A Minh, T.N.
%A Fievet, Nadine
%A Millet, P.
%T Immune response to Plasmodium falciparum liver stage antigen-1 : geographical variations within Central Africa and their relationship with protection from clinical malaria
%D 2000
%L fdi:010024068
%G ENG
%J Transactions of the Royal Society of Tropical Medicine and Hygiene
%@ 0035-9203
%K PALUDISME ; IMMUNOLOGIE ; ENFANT D'AGE SCOLAIRE ; VACCINATION ; ANTIGENE ; TEST ELISA ; ANTICORPS ; ANALYSE STATISTIQUE ; ETUDE REGIONALE ; ETUDE COMPARATIVE
%K LSA1.LIVER STAGE ANTIGEN 1 ; TNF ALPHA.TUMOR NECROSIS FACTOR ALPHA ; IFN GAMMA.INTERFERON GAMMA ; IL10.INTERLEUKIN 10 ; LPA.LYMPHOCYTE PROLIFERATIVE ASSAY ; CYTOKINE ; CELLULE T
%K CAMEROUN ; GABON
%K DIENGA ; POUMA
%N 5
%P 557-562
%R 10.1016/S0035-9203(00)90086-5
%U https://www.documentation.ird.fr/hor/fdi:010024068
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_57-58/010024068.pdf
%V 94
%W Horizon (IRD)
%X Two populations of schoolchildren from Gabon and Cameroon were tested in 1995 for their immunological reactivity to synthetic peptides (LSA-Rep, LSA-J and LSA-CTL) from #Plasmodium falciparum$ liver stage antigen-1 (LSA-1). The prevalence and levels of both cellular (lymphocyte proliferation, tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and interleukin-10 (IL-10)) and humoral (immunoglobulin G) responses were determined. Protection from clinical malaria, determined after a prospective 1 year study in both sites, was associated with elevated proliferative responses to LSA-Rep and LSA-CTL in the Gabonese children, as well as with higher antibody levels to both schizont extract and LSA-Rep. The prevalence of peptide-stimulated TNF-alpha secretion was higher in the Cameroonian group, but higher levels of antibodies to LSA-Rep and LSA-J were found in the Gabonese children. The immunological differences observed between children in the 2 study sites are discussed in the context of both epidemiological and individual host factors. (Résumé d'auteur)
%$ 052ANOPAL04