Immune response to Plasmodium falciparum liver stage antigen-1 : geographical variations within Central Africa and their relationship with protection from clinical malaria Migot Nabias, F. /Deloron, Philippe /Ringwald, Pascal Dubois, B. Mayombo, J. Minh, T.N. /Fievet, Nadine Millet, P. PALUDISME IMMUNOLOGIE ENFANT D'AGE SCOLAIRE VACCINATION ANTIGENE TEST ELISA ANTICORPS ANALYSE STATISTIQUE ETUDE REGIONALE ETUDE COMPARATIVE LSA1.LIVER STAGE ANTIGEN 1 TNF ALPHA.TUMOR NECROSIS FACTOR ALPHA IFN GAMMA.INTERFERON GAMMA IL10.INTERLEUKIN 10 LPA.LYMPHOCYTE PROLIFERATIVE ASSAY CYTOKINE CELLULE T Two populations of schoolchildren from Gabon and Cameroon were tested in 1995 for their immunological reactivity to synthetic peptides (LSA-Rep, LSA-J and LSA-CTL) from Plasmodium falciparum liver stage antigen-1 (LSA-1). The prevalence and levels of both cellular (lymphocyte proliferation, tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and interleukin-10 (IL-10)) and humoral (immunoglobulin G) responses were determined. Protection from clinical malaria, determined after a prospective 1 year study in both sites, was associated with elevated proliferative responses to LSA-Rep and LSA-CTL in the Gabonese children, as well as with higher antibody levels to both schizont extract and LSA-Rep. The prevalence of peptide-stimulated TNF-alpha secretion was higher in the Cameroonian group, but higher levels of antibodies to LSA-Rep and LSA-J were found in the Gabonese children. The immunological differences observed between children in the 2 study sites are discussed in the context of both epidemiological and individual host factors. (Résumé d'auteur) 2000 text https://www.documentation.ird.fr/hor/fdi:010024068 fdi:010024068 Migot Nabias F., Deloron Philippe, Ringwald Pascal, Dubois B., Mayombo J., Minh T.N., Fievet Nadine, Millet P.. Immune response to Plasmodium falciparum liver stage antigen-1 : geographical variations within Central Africa and their relationship with protection from clinical malaria. 2000, 94 (5), 557-562 EN CAMEROUN GABON