@article{fdi:010024068,
  title = {{I}mmune response to {P}lasmodium falciparum liver stage antigen-1 : geographical variations within {C}entral {A}frica and their relationship with protection from clinical malaria},
  author = {{M}igot {N}abias, {F}. and {D}eloron, {P}hilippe and {R}ingwald, {P}ascal and {D}ubois, {B}. and {M}ayombo, {J}. and {M}inh, {T}.{N}. and {F}ievet, {N}adine and {M}illet, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}wo populations of schoolchildren from {G}abon and {C}ameroon were tested in 1995 for their immunological reactivity to synthetic peptides ({LSA}-{R}ep, {LSA}-{J} and {LSA}-{CTL}) from #{P}lasmodium falciparum$ liver stage antigen-1 ({LSA}-1). {T}he prevalence and levels of both cellular (lymphocyte proliferation, tumour necrosis factor alpha ({TNF}-alpha), interferon gamma ({IFN}-gamma), and interleukin-10 ({IL}-10)) and humoral (immunoglobulin {G}) responses were determined. {P}rotection from clinical malaria, determined after a prospective 1 year study in both sites, was associated with elevated proliferative responses to {LSA}-{R}ep and {LSA}-{CTL} in the {G}abonese children, as well as with higher antibody levels to both schizont extract and {LSA}-{R}ep. {T}he prevalence of peptide-stimulated {TNF}-alpha secretion was higher in the {C}ameroonian group, but higher levels of antibodies to {LSA}-{R}ep and {LSA}-{J} were found in the {G}abonese children. {T}he immunological differences observed between children in the 2 study sites are discussed in the context of both epidemiological and individual host factors. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {IMMUNOLOGIE} ; {ENFANT} {D}'{AGE} {SCOLAIRE} ; {VACCINATION} ; {ANTIGENE} ; {TEST} {ELISA} ; {ANTICORPS} ; {ANALYSE} {STATISTIQUE} ; {ETUDE} {REGIONALE} ; {ETUDE} {COMPARATIVE} ; {LSA}1.{LIVER} {STAGE} {ANTIGEN} 1 ; {TNF} {ALPHA}.{TUMOR} {NECROSIS} {FACTOR} {ALPHA} ; {IFN} {GAMMA}.{INTERFERON} {GAMMA} ; {IL}10.{INTERLEUKIN} 10 ; {LPA}.{LYMPHOCYTE} {PROLIFERATIVE} {ASSAY} ; {CYTOKINE} ; {CELLULE} {T} ; {CAMEROUN} ; {GABON} ; {DIENGA} ; {POUMA}},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {94},
  numero = {5},
  pages = {557--562},
  ISSN = {0035-9203},
  year = {2000},
  DOI = {10.1016/{S}0035-9203(00)90086-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010024068},
}