@article{fdi:010022274,
  title = {{M}odifications of pyrethroid effects associated with kdr mutation in {A}nopheles gambiae},
  author = {{C}handre, {F}abrice and {D}arriet, {F}r{\'e}d{\'e}ric and {D}uchon, {S}. and {F}inot, {L}uc and {M}anguin, {S}ylvie and {C}arnevale, {P}ierre and {G}uillet, {P}ierre},
  editor = {},
  language = {{ENG}},
  abstract = {{E}ffects of knockdown resistance (kdr) were investigated in three pyrethroid-resistant ({PR}) strains of the {A}frotropical mosquito #{A}nopheles gambiae$ {G}iles ({D}iptera : {C}ulicidae) : {K}ou from {B}urkina {F}aso, {T}ola and {Y}ao from {C}{\^o}te d'{I}voire ; compared with a standard susceptible ({SS}) strain from {K}isumu, {K}enya. {T}he kdr factor was incompletly recessive, conferring 43-fold resistance ratio at {LD}50 level and 29-fold at {LD}95 level, as determinated by topical application tests with {K}ou strain. {W}hen adult mosquitoes were exposed to 0.25% permethrine-impregnated papers, the 50% and 95% knockdown times ({K}d{T}) were 23 and 42 min for {SS} females, compared with 40 and 62 min for {RS} ({F}1 {K}ou x {K}isumu) females. {O}n 1% permethrin the kdt50 and kdt95 were 11 and 21 min for {SS} compared with 18 and 33 min for {RS} females. {F}ollowing 1 h exposure to permethrin (0.25% or 1%), no significant knockdown of {K}ou {RR} females occurred within 24 h. {P}ermethrin irritancy to #{A}n. gambiae$ was assessed by comparing "time to first take-off" ({TO}) for females. {T}he standard {TO}50 and {TO}95 values for {K}isumu {SS} on untreated paper were 58 and 1044s, respectively, vs. 3.7 and 16.5s on 1% permethrin. {F}or {K}ou {RR} females the comparable values were 27.3s for {TO}50 and 294s for {TO}95, with intermediate {RS} values of 10.1s for {TO}50 and 71.9s for {TO}95. {T}hus, {TO} values for {RS} were 2.7-4.4 times more than for {SS}, and those for {RR} were 7-18 times longer than for {SS}. {E}xperiments with pyrethroid-impregnated nets were designed to induce hungry female mosquitoes to pass through holes cut in the netting. {L}aboratory "tunnels tests" used a bait guinea-pig to attract mosquitoes through circular holes (5 x 1 cm) in a net screen. {W}ith untreated netting, 75-83% of laboratory-reared females passed through the holes overnight, 63-69% blood-fed successfully and 9-17% died, with no significant differences between {SS} and {RR} genotypes... ({D}'apr{\`e}s r{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {VECTEUR} ; {MOUSTIQUE} ; {METHODE} {DE} {LUTTE} ; {MOUSTIQUAIRE} {IMPREGNEE} ; {INSECTICIDE} {CHIMIQUE} ; {SENSIBILITE} {RESISTANCE} ; {GENE} ; {MUTATION} ; {ETUDE} {COMPARATIVE} ; {PERMETHRINE} ; {DELTAMETHRINE} ; {GENE} {KDR} ; {COTE} {D}'{IVOIRE} ; {BURKINA} {FASO} ; {YAOKOFFIKRO}},
  booktitle = {},
  journal = {{M}edical and {V}eterinary {E}ntomology},
  volume = {14},
  numero = {1},
  pages = {81--88},
  ISSN = {0269-283{X}},
  year = {2000},
  DOI = {10.1046/j.1365-2915.2000.00212.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010022274},
}