%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Pradines, B.
%A Spiegel, A.
%A Rogier, C.
%A Tall, A.
%A Mosnier, J.
%A Fusai, T.
%A Trape, Jean-François
%A Parzy, D.
%T Antibiotics for prophylaxis of Plasmodium falciparum infections : in vitro activity of doxycycline against Senegalese isolates
%D 2000
%L fdi:010022262
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K PALUDISME ; TRAITEMENT MEDICAL ; PARASITE ; ANTIBIOTIQUE ; SENSIBILITE RESISTANCE ; CULTURE IN VITRO ; ETUDE COMPARATIVE
%K DOXYCYCLINE ; CHLOROQUINE ; AMODIAQUINE ; ARTEMETHER ; PYRIMETHAMINE ; CYCLOGUANIL
%K SENEGAL
%K DIELMO ; NDIOP
%N 1
%P 82-85
%U https://www.documentation.ird.fr/hor/fdi:010022262
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_55-56/010022262.pdf
%V 62
%W Horizon (IRD)
%X The in vitro acivities of doxycycline, chloroquine, quinine, amodiaquine, artemether, pyrimethamine, and cycloguanil were evaluated against #Plasmodium falciparum$ isolates from Senegal (Dielmo and Ndiop), using an isotopic, micro, drug susceptibility test. The 71 50% inhibitory concentration (IC50) values for doxycycline ranged from 0.7 to 108.0 microMol and the geometric mean IC50 for the 71 isolates was 11.3 microMol (95% confidence interval = 9.5-13.4 microM). The activity of doxycycline did not differ significantly (p = 0.0858) between the chloroquine-susceptible isolates and the chloroquine-resistant isolates. There was no in vitro correlation between the response to doxycycline and those to artemether, chloroquine, quinine, amodiaquine, pyrimethamine, and cycloguanil, suggesting no in vitro cross-resistance among these drugs. Potency was increased by prolonged exposure. In 96-hr incubations, the activity of doxycycline was 4-5 fold more increased than in 48-hr incubations. The in vitro activity of doxycycline against intraerythrocytic stages of multidrug-resistant #P. falciparum$, its action against the preerythrocytic forms, the lack of correlation between the responses in vitro of #P. falciparum$ to doxycycline and the other antimalarial drugs, and its original potential site of action are factors that favor its use as antimalarial drug. (Résumé d'auteur)
%$ 052ANOPAL04