@article{fdi:010022262,
  title = {{A}ntibiotics for prophylaxis of {P}lasmodium falciparum infections : in vitro activity of doxycycline against {S}enegalese isolates},
  author = {{P}radines, {B}. and {S}piegel, {A}. and {R}ogier, {C}. and {T}all, {A}. and {M}osnier, {J}. and {F}usai, {T}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {P}arzy, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he in vitro acivities of doxycycline, chloroquine, quinine, amodiaquine, artemether, pyrimethamine, and cycloguanil were evaluated against #{P}lasmodium falciparum$ isolates from {S}enegal ({D}ielmo and {N}diop), using an isotopic, micro, drug susceptibility test. {T}he 71 50% inhibitory concentration ({IC}50) values for doxycycline ranged from 0.7 to 108.0 micro{M}ol and the geometric mean {IC}50 for the 71 isolates was 11.3 micro{M}ol (95% confidence interval = 9.5-13.4 micro{M}). {T}he activity of doxycycline did not differ significantly (p = 0.0858) between the chloroquine-susceptible isolates and the chloroquine-resistant isolates. {T}here was no in vitro correlation between the response to doxycycline and those to artemether, chloroquine, quinine, amodiaquine, pyrimethamine, and cycloguanil, suggesting no in vitro cross-resistance among these drugs. {P}otency was increased by prolonged exposure. {I}n 96-hr incubations, the activity of doxycycline was 4-5 fold more increased than in 48-hr incubations. {T}he in vitro activity of doxycycline against intraerythrocytic stages of multidrug-resistant #{P}. falciparum$, its action against the preerythrocytic forms, the lack of correlation between the responses in vitro of #{P}. falciparum$ to doxycycline and the other antimalarial drugs, and its original potential site of action are factors that favor its use as antimalarial drug. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {TRAITEMENT} {MEDICAL} ; {PARASITE} ; {ANTIBIOTIQUE} ; {SENSIBILITE} {RESISTANCE} ; {CULTURE} {IN} {VITRO} ; {ETUDE} {COMPARATIVE} ; {DOXYCYCLINE} ; {CHLOROQUINE} ; {AMODIAQUINE} ; {ARTEMETHER} ; {PYRIMETHAMINE} ; {CYCLOGUANIL} ; {SENEGAL} ; {DIELMO} ; {NDIOP}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {62},
  numero = {1},
  pages = {82--85},
  ISSN = {0002-9637},
  year = {2000},
  URL = {https://www.documentation.ird.fr/hor/fdi:010022262},
}