@article{fdi:010021755,
  title = {{N}ear-full-length genome sequencing of divergent {A}frican {HIV} type 1 subtype {F} viruses leads to the identification of a new {HIV} type 1 subtype designated {K}},
  author = {{T}riques, {K}arine and {B}ourgeois, {A}. and {V}idal, {N}icole and {M}poudi {N}gol{\'e}, {E}. and {M}ulanga {K}abeya, {C}laire and {N}zilambi, {N}. and {T}orimiro, {N}. and {S}aman, {E}. and {D}elaporte, {E}ric and {P}eeters, {M}artine},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e recently reported a high divergence among {A}frican subtype {F} strains. {T}hree well-separated groups ({F}1, {F}2, and {F}3) have been shown based on the phylogenetic analysis of the p24 gag and envelope sequences with genetic distances similar to those observed for known subtypes. {I}n this study, we characterized the near-full-length genomes of two strains from epidemiological unlinked individual belonging to each of the subgroups : {F}1 (96{FR}-{MP}411), {F}2 (95{CM}-{MP}255 and 95{CM}-{MP}257), and {F}3 (96{CM}-{MP}535 and 97{ZR}-{EQTB}11). {P}hylogenetic analysis of the near-full-length sequences and for each of the genes separately showed the same three groups, supported by high bootstrap values. {D}iversity plotting, {BLAST} subtyping, and bootstrap plotting confirmed that the divergent {F} strains correspond to nonrecombinant viruses. {T}he divergence between {F}1 and {F}2 is consistently lower than that seen in any other intersubtype comparison, with the exception of subtypes {B} and {D}. {B}ased on all the different analyses, we propse to divide subtype {F} into two subclades, with {F}1 gathering the known subtype strains from {B}razil and {F}inland, and our {A}frican strain (96{FR}-{MP}411), and {F}2 containing the 95{CM}-{MP}255 and 95{CM}-{MP}257 strains from {C}ameroon. {T}he {F}3 strains, 97{ZR}-{EQTB}11 from the {D}emocratic {R}epublic of {C}ongo and 96{CM}-{MP}535 from {C}ameroon, meet the criteria of a new subtype designated as {K}. {T}he equidistance of subtype {K} to the other subtypes of {HIV}-1 suggests that this subtype existed as long as the others, the lower distance between {B} and {D}, and between {F}1 and {F}2 suggest a more recent subdivision for these latter strains. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {VIRUS} ; {STRUCTURE} {GENETIQUE} ; {GENOME} ; {PHYLOGENIE} ; {ANALYSE} {GENETIQUE} ; {VARIABILITE} {GENETIQUE} ; {DISTANCE} {GENETIQUE} ; {TECHNIQUE} {PCR} ; {ETUDE} {EXPERIMENTALE} ; {ETUDE} {COMPARATIVE} ; {RECOMBINAISON} {GENETIQUE} ; {AFRIQUE} ; {CAMEROUN} ; {CONGO} ; {TCHAD} ; {YOUGOSLAVIE}},
  booktitle = {},
  journal = {{AIDS} {R}esearch and {H}uman {R}etroviruses},
  volume = {16},
  numero = {2},
  pages = {139--151},
  ISSN = {0889-2229},
  year = {2000},
  DOI = {10.1089/088922200309485},
  URL = {https://www.documentation.ird.fr/hor/fdi:010021755},
}